MR Fat Fraction Mapping

Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children

OBJECTIVES To evaluate hepatic fat fraction on dual- and triple-echo gradient-recalled echo MRI sequences in healthy children. MATERIALS AND METHODS We retrospectively reviewed the records of children in a medical check-up clinic from May 2012 to November 2013. We excluded children with abnormal laboratory findings or those who were overweight. Hepatic fat fraction was measured on dual- and t...

Proton density fat-fraction: a standardized MR-based biomarker of tissue fat concentration.

Feasibility and reproducibility of MR fat-fraction measurements in muscle using iterative signal decomposition with a multifrequency fat signal model

Purpose: Duchenne muscular dystrophy (DMD) is a debilitating muscle disease characterized by progressive fatty muscle infiltration, muscle weakness and eventually death. Several therapeutic approaches have been recently developed. To accurately assess the effectiveness of these therapies at the tissue level, quantitative methods for patient follow up are essential because the standard method, b...

Measurement of liver fat fraction and iron with MRI and MR spectroscopy techniques.

Diffuse liver disease is a widespread global healthcare burden, and the abnormal accumulation of lipid and/or iron is common to important disease processes. Developing the improved methods for detecting and quantifying liver lipid and iron is an important clinical need. The inherent risk, invasiveness, and sampling error of liver biopsy have prompted the development of noninvasive imaging metho...

Breath-hold Quantitative Liver MR Imaging: Assessment of Hepatic Fibrosis, Iron Content, and Fat Fraction

Background: MRE is a phase contrast MRI technique that evaluates the stiffness of tissues by directly visualizing and measuring propagated mechanical shear waves in tissues. MRE generates quantitative measurements and colorized spatial maps of shear wave displacement. The initial wave images are processed to generate an elastogram, which displays the quantitative values of the shear modulus of ...